Novel piperidine derivatives as colchicine binding site inhibitors induce apoptosis and inhibit epithelial-mesenchymal transition against prostate cancer PC3 cells

• Autori principali: Dong-Jun Fu (Autore), Si-Meng Liu (Autore), Jia-Jia Yang (Autore), Jun Li (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Tubulin polymerisation inhibitors that target colchicine binding site were powerful anticancer agents. Although along the years many colchicine binding site inhibitors (CBSIs) have been reported, few piperidine derivatives were identified as CBSIs. In this regard, we focussed efforts on the piperidi...