RNA demethylase ALKBH5 promotes tumorigenesis of t (8;21) acute myeloid leukemia via ITPA m6A modification

• मुख्य लेखकों: Ran Li (लेखक), Xiaolu Wu (लेखक), Kai Xue (लेखक), Dandan Feng (लेखक), Jianyong Li (लेखक), Junmin Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Although t (8;21) is in fact considered a good risk acute myeloid leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have shown that RNA demethylase ALKBH5 promotes leukemogenesis. However, the molecular mechanism and clinical significance of AL...