RNA demethylase ALKBH5 promotes tumorigenesis of t (8;21) acute myeloid leukemia via ITPA m6A modification

Abstract Background Although t (8;21) is in fact considered a good risk acute myeloid leukemia (AML), only 60% of the patients live beyond 5 years after diagnosis. Studies have shown that RNA demethylase ALKBH5 promotes leukemogenesis. However, the molecular mechanism and clinical significance of AL...

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Main Authors: Ran Li (Author), Xiaolu Wu (Author), Kai Xue (Author), Dandan Feng (Author), Jianyong Li (Author), Junmin Li (Author)
Format: Book
Published: BMC, 2023-03-01T00:00:00Z.
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