Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice

• Main Authors: Weijun Ou (Author), Yuu Ohno (Author), Joshua Yang (Author), Devaraj V. Chandrashekar (Author), Tamara Abdullah (Author), Jiahong Sun (Author), Riley Murphy (Author), Chuli Roules (Author), Nataraj Jagadeesan (Author), David H. Cribbs (Author), Rachita K. Sumbria (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor necrosis factor alpha (TNF-α) plays a vital role in Alzheimer's disease (AD) pathology, and TNF-α inhibitors (TNFIs) modulate AD pathology. We fused the TNF-α receptor (TNFR), a biologic TNFI that sequesters TNF-α, to a transferrin receptor antibody (TfRMAb) to deliver the TNFI into the b...