Formulation of a Gastroretentive In Situ Oral Gel Containing Metformin HCl Based on DoE

• Main Authors: Jong Hee Kim (Author), Seung Hyun Song (Author), Sang Hoon Joo (Author), Gyu Hwan Park (Author), Kwon-Yeon Weon (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A gastroretentive in situ oral gel containing metformin hydrochloride (Met HCl) was prepared based on sodium alginate (Sod ALG), calcium carbonate, and hydroxyethylcellulose (HEC). The optimal composition of the formulation was explored based on the design of experiments (DoE). First, a 3<sup>...