Formulation of a Gastroretentive In Situ Oral Gel Containing Metformin HCl Based on DoE

• Hoofdauteurs: Jong Hee Kim (Auteur), Seung Hyun Song (Auteur), Sang Hoon Joo (Auteur), Gyu Hwan Park (Auteur), Kwon-Yeon Weon (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

A gastroretentive in situ oral gel containing metformin hydrochloride (Met HCl) was prepared based on sodium alginate (Sod ALG), calcium carbonate, and hydroxyethylcellulose (HEC). The optimal composition of the formulation was explored based on the design of experiments (DoE). First, a 3<sup>...