Design and analysis of stably integrated reporters for inducible transgene expression in human T cells and CAR NK-cell lines

• Main Authors: Sergey V. Kulemzin (Author), Daria A. Matvienko (Author), Artur H. Sabirov (Author), Arpine M. Sokratyan (Author), Daria S. Chernikova (Author), Tatyana N. Belovezhets (Author), Anton N. Chikaev (Author), Aleksandr V. Taranin (Author), Andrey A. Gorchakov (Author)
• Format: Book
• Published: BMC, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cytotoxic activity of T- and NK-cells can be efficiently retargeted against cancer cells using chimeric antigen receptors (CARs) and rTCRs. In the context of solid cancers, use of armored CAR T- and NK cells secreting additional anti-cancer molecules such as cytokines, chemokines...