Immunoinformatic of novel self-amplifying mRNA vaccine lipid nanoparticle against SARS-CoV-2

• Main Authors: Turmidzi Fath (Author), Endang Winiati Bachtiar (Author), Gulimiran Alitongbieke (Author), Yutian Pan (Author), Yuanqing Hu (Author), Retno Widowati (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We developed innovative self-amplifying mRNA (sa-mRNA) vaccine based on the derivative of S and Nsp3 proteins, which are considered crucial adhering to human host cells. We performed B-cell, Major histocompatibility complex (MHC) I, and II epitope which were merged with the KK and GPGPG linker. We a...