Chikungunya virus requires cellular chloride channels for efficient genome replication.

• Main Authors: Marietta Müller (Author), Natalie Slivinski (Author), Eleanor J A A Todd (Author), Henna Khalid (Author), Raymond Li (Author), Magdalena Karwatka (Author), Andres Merits (Author), Jamel Mankouri (Author), Andrew Tuplin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chikungunya virus (CHIKV) is a re-emerging, pathogenic alphavirus that is transmitted to humans by Aedes spp. mosquitoes-causing fever and debilitating joint pain, with frequent long-term health implications and high morbidity. The CHIKV lifecycle is poorly understood and specific antiviral therapeu...