Safety and Pharmacokinetic Assessment of Oral Proglumide in Those with Hepatic Impairment

• Main Authors: Christine C. Hsu (Author), Sunil Bansal (Author), Hong Cao (Author), Coleman I. Smith (Author), Aiwu Ruth He (Author), Martha D. Gay (Author), Yaoxiang Li (Author), Amrita Cheema (Author), Jill P. Smith (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proglumide is an orally administered cholecystokinin receptor antagonist that was found to improve nonalcoholic steatohepatitis, reverse liver fibrosis, and decrease incidence of hepatocellular carcinoma (HCC) in animal models. The current investigation aimed to test the pharmacokinetics and safety...