Improvement of the Antibacterial Activity of Phage Lysin-Derived Peptide P87 through Maximization of Physicochemical Properties and Assessment of Its Therapeutic Potential

• Главные авторы: Roberto Vázquez (Автор), Antonio Doménech-Sánchez (Автор), Susana Ruiz (Автор), Julio Sempere (Автор), Jose Yuste (Автор), Sebastián Albertí (Автор), Pedro García (Автор)
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• Опубликовано: MDPI AG, 2022-10-01T00:00:00Z.
• Предметы: article
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Phage lysins are a promising alternative to common antibiotic chemotherapy. However, they have been regarded as less effective against Gram-negative pathogens unless engineered, e.g., by fusing them to antimicrobial peptides (AMPs). AMPs themselves pose an alternative to antibiotics. In this work, A...