Hyperthermia based individual in situ recombinant vaccine enhances lymph nodes drainage for de novo antitumor immunity

• Main Authors: Cuixia Zheng (Author), Xinxin Liu (Author), Yueyue Kong (Author), Lei Zhang (Author), Qingling Song (Author), Hongjuan Zhao (Author), Lu Han (Author), Jiannan Jiao (Author), Qianhua Feng (Author), Lei Wang (Author)
• Format: Book
• Published: Elsevier, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The continuing challenges that limit effectiveness of tumor therapeutic vaccines were high heterogeneity of tumor immunogenicity, low bioactivity of antigens, as well as insufficient lymph nodes (LNs) drainage of antigens and adjuvants. Transportation of in situ neoantigens and adjuvants to LNs may...