Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions

• Main Authors: Yuanyuan Li (Author), Xiaokun Cheng (Author), Xinying Liu (Author), Le Wang (Author), Jing Ha (Author), Zibin Gao (Author), Xiaoliang He (Author), Zhuo Wu (Author), Aibing Chen (Author), Linda L. Jewell (Author), Yongjun Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA receptors. However, recent studies have shown that...