Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation

• Main Authors: Amy R. Johnson (Author), Yuanyuan Qin (Author), Alyssa J. Cozzo (Author), Alex J. Freemerman (Author), Megan J. Huang (Author), Liyang Zhao (Author), Brante P. Sampey (Author), J. Justin Milner (Author), Melinda A. Beck (Author), Blossom Damania (Author), Naim Rashid (Author), Joseph A. Galanko (Author), Douglas P. Lee (Author), Matthew L. Edin (Author), Darryl C. Zeldin (Author), Patrick T. Fueger (Author), Brittney Dietz (Author), Andreas Stahl (Author), Ying Wu (Author), Karen L. Mohlke (Author), Liza Makowski (Author)
• Format: Book
• Published: Elsevier, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A novel approach to regulate obesity-associated adipose inflammation may be through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs dependent on glucose are pro-inflammatory, classically activated MΦs (CAM), which contribute to adipose inflammation and insulin resistan...