Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever

• Main Authors: G. Varga (Author), S. Schleifenbaum (Author), U. Koenig (Author), J. Waldkirch (Author), C. Hinze (Author), C. Kessel (Author), W. Geluk (Author), T. Pap (Author), Elke Lainka (Author), Tilmann Kallinich (Author), D. Foell (Author), H. Wittkowski (Author)
• Format: Book
• Published: SpringerOpen, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Familial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations are the genetic basis of this disease, and its expression has been shown in monocytes, granulocytes, dendritic cells, and synovial fibroblast...