Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.

• Asıl Yazarlar: Lorenzo Cianni (Yazar), Carina Lemke (Yazar), Erik Gilberg (Yazar), Christian Feldmann (Yazar), Fabiana Rosini (Yazar), Fernanda Dos Reis Rocho (Yazar), Jean F R Ribeiro (Yazar), Daiane Y Tezuka (Yazar), Carla D Lopes (Yazar), Sérgio de Albuquerque (Yazar), Jürgen Bajorath (Yazar), Stefan Laufer (Yazar), Andrei Leitão (Yazar), Michael Gütschow (Yazar), Carlos A Montanari (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map its S1/S1´ subsites. The same series was evaluated o...