Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents.
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map its S1/S1´ subsites. The same series was evaluated o...
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Egile Nagusiak: | , , , , , , , , , , , , , , |
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Formatua: | Liburua |
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Public Library of Science (PLoS),
2020-03-01T00:00:00Z.
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Internet
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A1234.567 |
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Alea 1 | Eskuragarri |