Molecular mechanism of the spider toxin κ-LhTx-I acting on the bacterial voltage-gated sodium channel NaChBac

• Main Authors: Zhen Xiao (Author), Yaqi Li (Author), Piao Zhao (Author), Xiangyue Wu (Author), Guoqing Luo (Author), Shuijiao Peng (Author), Hongrong Liu (Author), Cheng Tang (Author), Zhonghua Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bacterial sodium channel NaChBac is the prokaryotic prototype for the eukaryotic NaV and CaV channels, which could be used as a relatively simple model to study their structure-function relationships. However, few modulators of NaChBac have been reported thus far, and the pharmacology of NaChBac...