Molecular mechanism of the spider toxin κ-LhTx-I acting on the bacterial voltage-gated sodium channel NaChBac

• Hoofdauteurs: Zhen Xiao (Auteur), Yaqi Li (Auteur), Piao Zhao (Auteur), Xiangyue Wu (Auteur), Guoqing Luo (Auteur), Shuijiao Peng (Auteur), Hongrong Liu (Auteur), Cheng Tang (Auteur), Zhonghua Liu (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The bacterial sodium channel NaChBac is the prokaryotic prototype for the eukaryotic NaV and CaV channels, which could be used as a relatively simple model to study their structure-function relationships. However, few modulators of NaChBac have been reported thus far, and the pharmacology of NaChBac...