An intravenous clarithromycin lipid emulsion with a high drug loading, H-bonding and a hydrogen-bonded ion pair complex exhibiting excellent antibacterial activity

• Main Authors: Haoyu Gong (Author), Sicong Geng (Author), Qi Zheng (Author), Puxiu Wang (Author), Lifeng Luo (Author), Xiuzhi Wang (Author), Yan Zhang (Author), Yu Zhang (Author), Haibing He (Author), Xing Tang (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to develop an intravenous clarithromycin lipid emulsion (CLE) with good stability and excellent antibacterial activity. The CLE was prepared by the thin-film dispersed homogenization method. The interaction between clarithromycin (CLA) and cholesteryl hemisuccinate (CHEMS)...