Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani.

• Main Authors: Sanchita Das (Author), Priyanka Shah (Author), Rati Tandon (Author), Narendra Kumar Yadav (Author), Amogh A Sahasrabuddhe (Author), Shyam Sundar (Author), Mohammad Imran Siddiqi (Author), Anuradha Dube (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Resistance emergence against antileishmanial drugs, particularly Sodium Antimony Gluconate (SAG) has severely hampered the therapeutic strategy against visceral leishmaniasis, the mechanism of resistance being indistinguishable. Cysteine leucine rich protein (CLrP), was recognized as one...