Sphingomyelin Synthase 1 (SMS1) Downregulation Is Associated With Sphingolipid Reprogramming and a Worse Prognosis in Melanoma

• मुख्य लेखकों: Fatima Bilal (लेखक), Anne Montfort (लेखक), Julia Gilhodes (लेखक), Virginie Garcia (लेखक), Joëlle Riond (लेखक), Stéphane Carpentier (लेखक), Thomas Filleron (लेखक), Céline Colacios (लेखक), Thierry Levade (लेखक), Ahmad Daher (लेखक), Nicolas Meyer (लेखक), Nathalie Andrieu-Abadie (लेखक), Bruno Ségui (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Sphingolipid (SL) metabolism alterations have been frequently reported in cancer including in melanoma, a bad-prognosis skin cancer. In normal cells, de novo synthesized ceramide is mainly converted to sphingomyelin (SM), the most abundant SL, by sphingomyelin synthase 1 (SMS1) and, albeit to a less...