Airway Basal Cells Mediate Hypoxia-Induced EMT by Increasing Ribosome Biogenesis

• Main Authors: Yapeng Hou (Author), Yan Ding (Author), Danni Du (Author), Tong Yu (Author), Wei Zhou (Author), Yong Cui (Author), Hongguang Nie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive secretion of airway mucus and fluid accumulation are the common features of many respiratory diseases, which, in turn, induce cell hypoxia in the airway epithelium, resulting in epithelial-mesenchymal transition (EMT) and ultimately fibrosis. However, the mechanisms of EMT induced by hypox...