Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1

• Main Authors: Panagiota Pantiora (Author), Veronika Furlan (Author), Dimitris Matiadis (Author), Barbara Mavroidi (Author), Fereniki Perperopoulou (Author), Anastassios C. Papageorgiou (Author), Marina Sagnou (Author), Urban Bren (Author), Maria Pelecanou (Author), Nikolaos E. Labrou (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the inhibition potency of two curcuminoids and eleven monocarbonyl curcumin analogues against hGSTP1-1 was investigated. Demethoxy...