A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata

• Main Authors: Samira Anderson (Author), Guido Cavaletti (Author), Linda J. Hood (Author), Michael Polydefkis (Author), David N. Herrmann (Author), Gary Rance (Author), Brett King (Author), Amy J. McMichael (Author), Maryanne M. Senna (Author), Brian S. Kim (Author), Lynne Napatalung (Author), Robert Wolk (Author), Samuel H. Zwillich (Author), Gregor Schaefer (Author), Yankun Gong (Author), Melanie Sisson (Author), Holly B. Posner (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Reversible axonal swelling and brainstem auditory evoked potential (BAEP) changes were observed in standard chronic (9‐month) toxicology studies in dogs treated with ritlecitinib, an oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor, at exposu...