Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway

• Main Authors: Hongtian Zhu (Author), Lei Tang (Author), Chenghong Zhang (Author), Baochu Wei (Author), Pingrong Yang (Author), Dian He (Author), Lifang Zheng (Author), Yang Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chalcone derivatives, as a hot research field, exhibit a variety of physiological bioactivities and target multiple biological receptors. Based on the skeleton of (E)-1,3-diphenyl-2-propene-1-one, 14 chalcone derivatives were designed and synthesized, and evaluated as the antitumor candidates agents...