Rickettsiae induce microvascular hyperpermeability via phosphorylation of VE-cadherins: evidence from atomic force microscopy and biochemical studies.

• मुख्य लेखकों: Bin Gong (लेखक), Liang Ma (लेखक), Yan Liu (लेखक), Qinyu Gong (लेखक), Thomas Shelite (लेखक), Donald Bouyer (लेखक), Paul J Boor (लेखक), Yong Sun Lee (लेखक), Andres Oberhauser (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The most prominent pathophysiological effect of spotted fever group (SFG) rickettsial infection of microvascular endothelial cells (ECs) is an enhanced vascular permeability, promoting vasogenic cerebral edema and non-cardiogenic pulmonary edema, which are responsible for most of the morbidity and m...