Rickettsiae induce microvascular hyperpermeability via phosphorylation of VE-cadherins: evidence from atomic force microscopy and biochemical studies.

• Main Authors: Bin Gong (Author), Liang Ma (Author), Yan Liu (Author), Qinyu Gong (Author), Thomas Shelite (Author), Donald Bouyer (Author), Paul J Boor (Author), Yong Sun Lee (Author), Andres Oberhauser (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The most prominent pathophysiological effect of spotted fever group (SFG) rickettsial infection of microvascular endothelial cells (ECs) is an enhanced vascular permeability, promoting vasogenic cerebral edema and non-cardiogenic pulmonary edema, which are responsible for most of the morbidity and m...