Development of Large Hollow Particles for Pulmonary Delivery of Cyclosporine A

• Main Authors: Yongpeng Huang (Author), Hui Tang (Author), Xiangyan Meng (Author), Zitong Zhao (Author), Yanli Liu (Author), Dongxin Liu (Author), Bo Chen (Author), Zhiyun Zou (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to prepare large hollow particles (LHPs) by spray drying for pulmonary delivery of cyclosporine A (CsA), using L-Leucine (LEU) and hydroxypropyl methylcellulose (HPMC) as excipients and ammonium bicarbonate (AB) as a porogen. The prepared LHPs were spherical particles c...