The Chinese herb Styrax triggers pharmacokinetic herb-drug interactions via inhibiting intestinal CYP3A

• Main Authors: Feng Zhang (Author), Tiantian Zhang (Author), Jiahao Gong (Author), Qinqin Fang (Author), Shenglan Qi (Author), Mengting Li (Author), Yan Han (Author), Wei Liu (Author), Guangbo Ge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human cytochrome P450 3A4 (hCYP3A4) is a predominant enzyme to trigger clinically relevant drug/herb-drug interactions (DDIs or HDIs). Although a number of herbal medicines have been found with strong anti-hCYP3A4 effects in vitro, the in vivo modulatory effects of herbal medicines on hCYP3A4 and th...