The Chinese herb Styrax triggers pharmacokinetic herb-drug interactions via inhibiting intestinal CYP3A

• 主要な著者: Feng Zhang (著者), Tiantian Zhang (著者), Jiahao Gong (著者), Qinqin Fang (著者), Shenglan Qi (著者), Mengting Li (著者), Yan Han (著者), Wei Liu (著者), Guangbo Ge (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Human cytochrome P450 3A4 (hCYP3A4) is a predominant enzyme to trigger clinically relevant drug/herb-drug interactions (DDIs or HDIs). Although a number of herbal medicines have been found with strong anti-hCYP3A4 effects in vitro, the in vivo modulatory effects of herbal medicines on hCYP3A4 and th...