The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo

• Main Authors: Sara Vaccaro (Author), Alessandra Rossetti (Author), Antonella Porrazzo (Author), Simona Camero (Author), Matteo Cassandri (Author), Silvia Pomella (Author), Miriam Tomaciello (Author), Giampiero Macioce (Author), Francesca Pedini (Author), Giovanni Barillari (Author), Cinzia Marchese (Author), Rossella Rota (Author), Giovanni Cenci (Author), Mario Tombolini (Author), Robert A. Newman (Author), Peiying Yang (Author), Silvia Codenotti (Author), Alessandro Fanzani (Author), Francesca Megiorni (Author), Claudio Festuccia (Author), Giuseppe Minniti (Author), Giovanni Luca Gravina (Author), Francesca Vulcano (Author), Luisa Milazzo (Author), Francesco Marampon (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanisms of resistance to therapies, despite improvements...