RUBY® - a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties

• Main Authors: Barnabas Nyesiga (Author), Mattias Levin (Author), Anna Säll (Author), Anna Rosén (Author), Kim Jansson (Author), Sara Fritzell (Author), Karin Hägerbrand (Author), Dietmar Weilguny (Author), Laura von Schantz (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTDespite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. Here, we present RUBY, a novel bispecific antibody format that allows rapid generation of bsAbs that fulfill key developme...