Isorhynchophylline Exerts Antinociceptive Effects on Behavioral Hyperalgesia and Allodynia in a Mouse Model of Neuropathic Pain: Evidence of a 5-HT1A Receptor-Mediated Mechanism

• Autores principales: Ke-Xin Gao (Autor), Qing Zhao (Autor), Gang-Ren Wang (Autor), Lu Yu (Autor), Jia-Yi Wu (Autor), Xin Zhao (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Chronic neuropathic pain poses a significant health problem, for which effective therapy is lacking. The current work aimed to investigate the potential antinociceptive efficacy of isorhynchophylline, an oxindole alkaloid, against neuropathic pain and elucidate mechanisms. Male C57BL/6J mice were su...