Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death

• المؤلفون الرئيسيون: Stephen John Ralph (مؤلف), Rhys Pritchard (مؤلف), Sara Rodríguez-Enríquez (مؤلف), Rafael Moreno-Sánchez (مؤلف), Raymond Keith Ralph (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2015-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Tumor metastases that impede the function of vital organs are a major cause of cancer related mortality. Mitochondrial oxidative stress induced by hypoxia, low nutrient levels, or other stresses, such as genotoxic events, act as key drivers of the malignant changes in primary tumors to enhance their...