TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization

• Main Authors: Lifang Zhao (Author), Hongyan Zhang (Author), Xueqing Liu (Author), Shan Xue (Author), Dongfang Chen (Author), Jing Zou (Author), Handong Jiang (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and plays a critical role in regulating inflammatory response. Our previous work has shown its role in promoting the progression of non-small cell lung cancer (NSCLC), yet the mechanism remains unclea...