TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization

• Hauptverfasser: Lifang Zhao (Verfasst von), Hongyan Zhang (Verfasst von), Xueqing Liu (Verfasst von), Shan Xue (Verfasst von), Dongfang Chen (Verfasst von), Jing Zou (Verfasst von), Handong Jiang (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2022-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and plays a critical role in regulating inflammatory response. Our previous work has shown its role in promoting the progression of non-small cell lung cancer (NSCLC), yet the mechanism remains unclea...