Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

• Main Authors: Xiaowei Zhang (Author), Ping Zhang (Author), Lin An (Author), Ningyuan Sun (Author), Liying Peng (Author), Weiwei Tang (Author), Dingyuan Ma (Author), Jun Chen (Author)
• Format: Book
• Published: Elsevier, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge, has been shown to possess anti-cancer activities....