Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha

• Main Authors: Guolin Li (Author), Chad N. Brocker (Author), Tingting Yan (Author), Cen Xie (Author), Kristopher W. Krausz (Author), Rong Xiang (Author), Frank J. Gonzalez (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Peroxisome proliferator-activated receptor alpha (PPARA) is a major regulator of fatty acid oxidation and severe hepatic steatosis occurs during acute fasting in Ppara-null mice. Thus, PPARA is considered an important mediator of the fasting response; however, its role in other fasting r...