T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics

• Huvudskapare: Ruoxuan Sun (Författare, medförfattare), Mark G. Qian (Författare, medförfattare), Xiaobin Zhang (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

ABSTRACTThe surge in the clinical use of therapeutic antibodies has reshaped the landscape of pharmaceutical therapy for many diseases, including rare and challenging conditions. However, the administration of exogenous biologics could potentially trigger unwanted immune responses such as generation...