Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

• Main Authors: Jin Feng (Author), Xiaohui Wang (Author), Xiaochun Ye (Author), Irma Ares (Author), Bernardo Lopez-Torres (Author), Marta Martínez (Author), María-Rosa Ma (Author), Xu Wang (Author), Arturo Anadón (Author), María-Aránzazu Martínez (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metformin is the oldest and most commonly used first-line antidiabetic drug because of its good clinical efficacy, high safety, low cost and easy access. At the same time, in recent years, we have found that its role as a therapeutic drug is gradually expanding. A large number of basic studies have...