Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

• Egile Nagusiak: Jin Feng (Egilea), Xiaohui Wang (Egilea), Xiaochun Ye (Egilea), Irma Ares (Egilea), Bernardo Lopez-Torres (Egilea), Marta Martínez (Egilea), María-Rosa Ma (Egilea), Xu Wang (Egilea), Arturo Anadón (Egilea), María-Aránzazu Martínez (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Metformin is the oldest and most commonly used first-line antidiabetic drug because of its good clinical efficacy, high safety, low cost and easy access. At the same time, in recent years, we have found that its role as a therapeutic drug is gradually expanding. A large number of basic studies have...