Interference of Interleukin-1β Mediated by Lentivirus Promotes Functional Recovery of Spinal Cord Contusion Injury in Rats via the PI3K/AKT1 Signaling Pathway

• Main Authors: Jun-Feng Cao (Author), Xi Hu (Author), Li Xiong (Author), Mei Wu (Author), Xingyu Yang (Author), Chaochao Wang (Author), Shengyan Chen (Author), Hengxiang Xu (Author), Huanyu Chen (Author), Xuntai Ma (Author), Yongjie Mi (Author), Xiao Zhang (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Inflammation and apoptosis after spinal cord contusion (SCC) are important causes of irreversible spinal cord injury. Interleukin-1β (IL-1β) is a key inflammatory factor that promotes the aggravation of spinal cord contusion. However, the specific role and regulatory mechanism of IL-1β in s...