The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies

• Main Authors: Julieta María Sánchez (Author), José Vicente Carratalá (Author), Naroa Serna (Author), Ugutz Unzueta (Author), Verónica Nolan (Author), Alejandro Sánchez-Chardi (Author), Eric Voltà-Durán (Author), Hèctor López-Laguna (Author), Neus Ferrer-Miralles (Author), Antonio Villaverde (Author), Esther Vazquez (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The coordination between histidine-rich peptides and divalent cations supports the formation of nano- and micro-scale protein biomaterials, including toxic and non-toxic functional amyloids, which can be adapted as drug delivery systems. Among them, inclusion bodies (IBs) formed in recombinant bacte...