Acetic Acid as Processing Aid Dramatically Improves Organic Solvent Solubility of Weakly Basic Drugs for Spray Dried Dispersion Manufacture

• المؤلفون الرئيسيون: Molly S. Adam (مؤلف), Warren K. Miller (مؤلف), Amanda M. Pluntze (مؤلف), Aaron M. Stewart (مؤلف), Jonathan L. Cape (مؤلف), Michael E. Grass (مؤلف), Michael M. Morgen (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Many active pharmaceutical ingredients (APIs) in the pharmaceutical pipeline require bioavailability enhancing formulations due to very low aqueous solubility. Although spray dried dispersions (SDDs) have demonstrated broad utility in enhancing the bioavailability of such APIs by trapping them in a...