Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC

• Main Authors: Rachel D. Hutchison (Author), Benjamin M. Ford (Author), Lirit N. Franks (Author), Catheryn D. Wilson (Author), Azure L. Yarbrough (Author), Ryoichi Fujiwara (Author), Mark K. Su (Author), Denise Fernandez (Author), Laura P. James (Author), Jeffery H. Moran (Author), Amy L. Patton (Author), William E. Fantegrossi (Author), Anna Radominska-Pandya (Author), Paul L. Prather (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recreational use of marijuana is associated with few adverse effects, but abuse of synthetic cannabinoids (SCBs) can result in anxiety, psychosis, chest pain, seizures and death. To potentially explain higher toxicity associated with SCB use, we hypothesized that AB-PINACA, a common second generatio...