Targeting DEC-205−DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis

• Main Authors: Inna Tabansky (Author), Derin B. Keskin (Author), Deepika Watts (Author), Cathleen Petzold (Author), Michael Funaro (Author), Warren Sands (Author), Paul Wright (Author), Edmond J. Yunis (Author), Souhel Najjar (Author), Betty Diamond (Author), Yonghao Cao (Author), David Mooney (Author), Karsten Kretschmer (Author), Joel N. H. Stern (Author)
• Format: Book
• Published: BMC, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Dendritic cells (DC) induce adaptive responses against foreign antigens, and play an essential role in maintaining peripheral tolerance to self-antigens. Therefore they are involved in preventing fatal autoimmunity. Selective delivery of antigens to immature DC via the endocytic...