The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents

• Ngā kaituhi matua: Jiabei Zhou (Author), Yu Kang (Author), Lu Chen (Author), Hua Wang (Author), Junqing Liu (Author), Su Zeng (Author), Lushan Yu (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin, and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or acquired resistance severely limit the clinical application of platinum-based treatment. The underlying mechanisms are i...