Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators

• Main Authors: Jian Gao (Author), Qing-Qing Chen (Author), Ye Huang (Author), Kai-Hang Li (Author), Xiao-Ju Geng (Author), Tao Wang (Author), Qi-Si Lin (Author), Ruo-Si Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic nephropathy (DN) is one of the most important medical complications in diabetic patients, which is an essential cause of end-stage renal disease in diabetic patients and still lacks effective medicines. Silent information regulator 1 (SIRT1) is closely related to the occurrence and developm...