Effect of Ultraviolet B Irradiation on Melanin Content Accompanied by the Activation of p62/GATA4-Mediated Premature Senescence in HaCaT Cells

• Main Authors: Juan Yan (Author), Li-Ping Ma (Author), Fang Liu (Author), Bo Sun (Author), Mei Tian (Author), Xue Lu (Author), Hai-Xiang Liu (Author), Ling Gao (Author), Qing-Jie Liu (Author)
• Format: Book
• Published: SAGE Publishing, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective To explore the effect and mechanism of ultraviolet B (UVB) on melanin synthesis and premature senescence in human immortalized keratinocytes (HaCaT) cells. Methods HaCaT cells were irradiated with 0, 20, 50, 80, 100, 150, and 200 mJ/cm 2 of UVB. NaOH method was used for melanin content ass...