Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway

• Main Authors: Qin Dai (Author), Yan Zhang (Author), Xiaohua Liao (Author), Yupeng Jiang (Author), Xin Lv (Author), Xiangning Yuan (Author), Jie Meng (Author), Yanyun Xie (Author), Zhangzhe Peng (Author), Qiongjing Yuan (Author), LiJian Tao (Author), Ling Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell death and sterile inflammation are major mechanisms of renal fibrosis, which eventually develop into end-stage renal disease. "Necroptosis" is a type of caspase-independent regulated cell death, and sterile inflammatory response caused by tissue injury is strongly related to necrosis....