Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation

• Main Authors: Ahmed Sabry Mohamed (Author), Mahmoud ElKaffas (Author), Karim Metwally (Author), Mahmoud Abdelfattah (Author), Eslam Ashraf Elsery (Author), Ahmed Elshazly (Author), Hossam Eldin Gomaa (Author), Aziza Alsayed (Author), Sara El-Desouky (Author), Randa El-Gamal (Author), Sara Elfarrash (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation of abundant hyperphoshorylated tau filaments, the associated neuroinflammation and disease phenotype. However, the exact underpinning mechanisms are still not fully add...