Immunomodulatory and Antibacterial Effects of Cystatin 9 against Francisella tularensis

• Main Authors: Tonyia Eaves-Pyles (Author), Jignesh Patel (Author), Emma Arigi (Author), Yingzi Cong (Author), Anthony Cao (Author), Nisha Garg (Author), Monisha Dhiman (Author), Richard B. Pyles (Author), Bernard Arulanandam (Author), Aaron L. Miller (Author), Vsevolod L. Popov (Author), Lynn Soong (Author), Eric D. Carlsen (Author), Ciro Coletta (Author), Csaba Szabo (Author), Igor C. Almeida (Author)
• Format: Book
• Published: BMC, 2013-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections are unknown. Here, we report that purified human recombinant (r)CST9 protects agai...