Tapentadol shows lower intrinsic efficacy at µ receptor than morphine and oxycodone
Abstract Tapentadol is a centrally acting analgesic with a dual mechanism of action. It acts as an agonist at the µ receptor and inhibitor of noradrenaline reuptake. Clinical trials suggest similar analgesic efficacy of tapentadol, oxycodone, and morphine in acute and chronic pain. Given the limited...
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Wiley,
2022-02-01T00:00:00Z.
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