WBC count and functional changes induced by co-administration of clofazimine and clarithromycin, in single and multiple doses, in Wistar rats

• Main Authors: Flávia Aparecida Paina (Author), Julise Cunha Miranda (Author), Cristiane Fernandes de Freitas Tavares (Author), Regina Helena da Costa Queiroz (Author), Ana Maria de Souza (Author)
• Format: Book
• Published: Universidade de São Paulo, 2012-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clofazimine and clarithromycin are used to treat leprosy and infections caused by Mycobacterium avium complex. Little data on the toxicity of co-administration of these two drugs are available. Here we evaluated the potential adverse effects of polytherapy with these two drugs in male Wistar rats by...