Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins.

• Main Authors: Murilo Sena Amaral (Author), Ernesto Goulart (Author), Luiz Carlos Caires-Júnior (Author), David Abraham Morales-Vicente (Author), Alessandra Soares-Schanoski (Author), Roselane Paiva Gomes (Author), Giovanna Gonçalves de Oliveira Olberg (Author), Renato Mancini Astray (Author), Jorge E Kalil (Author), Mayana Zatz (Author), Sergio Verjovski-Almeida (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zika virus (ZIKV) causes congenital Zika syndrome (CZS), which is characterized by fetal demise, microcephaly and other abnormalities. ZIKV in the pregnant woman circulation must cross the placental barrier that includes fetal endothelial cells and trophoblasts, in order to reach the fetus. CZS occu...