Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen

• Main Authors: Yaxin Fan (Author), Yi Li (Author), Yuancheng Chen (Author), Jicheng Yu (Author), Xiaofen Liu (Author), Wanzhen Li (Author), Beining Guo (Author), Xin Li (Author), Jingjing Wang (Author), Hailan Wu (Author), Yu Wang (Author), Jiali Hu (Author), Yan Guo (Author), Fupin Hu (Author), Xiaoyong Xu (Author), Guoying Cao (Author), Jufang Wu (Author), Yingyuan Zhang (Author), Jing Zhang (Author), Xiaojie Wu (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colistin methanesulfonate (CMS) is an important treatment option for infections caused by carbapenem-resistant Gram-negative organisms (CROs). This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) profiles and safety of CMS in Chinese subjects following a recommended dosage. A total of 12...