Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson's Disease in Rats: Formulation, Optimization, Characterization, and In Vivo Evaluation

• Main Authors: Mohd Imran (Author), Mazen Almehmadi (Author), Ahad Amer Alsaiari (Author), Mehnaz Kamal (Author), Mohammed Kanan Alshammari (Author), Mohammed Omar Alzahrani (Author), Faisal Khaled Almaysari (Author), Abdulrahman Omar Alzahrani (Author), Ahmed Faraj Elkerdasy (Author), Sachin Kumar Singh (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A mucoadhesive microemulsion of lipophilic silymarin (SLMMME) was developed to treat Parkinson's disease (PD). Optimization of the SLM microemulsion (ME) was performed using Central Composite Design (CCD). The composition of oil, surfactant, co-surfactant, and water was varied, as per the desig...